Nucpaedia
Nucpaedia
Theranostics

Therapy guides

Pick a therapy for a step-by-step guide to run alongside treatment — organised into before planning therapy, during therapy and after each cycle, with tick-boxes and patient-counselling prompts.

Educational aid — not a substitute for clinical judgement. Verify every step, dose and threshold against current EANM / SNMMI / ATA / NCCN guidance, the drug label and your local protocol. Session-only — no patient details are stored.
Cancer radionuclide therapy
Radionuclide therapy · NET · PRRT¹⁷⁷Lu-DOTATATEPeptide receptor radionuclide therapy for progressive SSTR-expressing neuroendocrine tumours.3 phases · 19 stepsOpen guide →Radionuclide therapy · mCRPC¹⁷⁷Lu-PSMA-617PSMA radioligand therapy for progressive metastatic castration-resistant prostate cancer.3 phases · 15 stepsOpen guide →Radionuclide therapy · Differentiated thyroid cancer¹³¹I (thyroid)Radioiodine therapy for differentiated thyroid cancer (remnant ablation, adjuvant or metastatic).3 phases · 15 stepsOpen guide →Radionuclide therapy · mCRPC · bone-only metastases²²³Ra-dichloride (Xofigo)Targeted α therapy for castration-resistant prostate cancer with symptomatic bone metastases and no known visceral disease.3 phases · 33 stepsOpen guide →Radionuclide therapy · HCC · liver metastases⁹⁰Y SIRT (radioembolisation)Selective internal radiation therapy with ⁹⁰Y resin or glass microspheres (and ¹⁶⁶Ho microspheres) delivered through the hepatic artery for primary and metastatic liver tumours.3 phases · 35 stepsOpen guide →Radionuclide therapy · Neuroblastoma · phaeochromocytoma/paraganglioma¹³¹I-MIBG therapyTargeted radionuclide therapy with ¹³¹I-meta-iodobenzylguanidine for MIBG-avid relapsed or refractory high-risk neuroblastoma and metastatic or inoperable phaeochromocytoma and paraganglioma.3 phases · 33 stepsOpen guide →
Benign disease & palliation
Radionuclide therapy · Graves · toxic nodular goitre¹³¹I for hyperthyroidismOral radioiodine as definitive treatment for Graves' disease, toxic multinodular goitre and toxic adenoma, with fixed or dosimetry-based activity.3 phases · 35 stepsOpen guide →Radionuclide therapy · Persistent synovitis · haemophilia · PVNSRadiosynovectomy (radiosynoviorthesis)Intra-articular β-emitting radiocolloid for persistent synovitis of one or a few joints, matched to joint size: ⁹⁰Y knee, ¹⁸⁶Re medium joints, ¹⁶⁹Er small joints.3 phases · 33 stepsOpen guide →Radionuclide therapy · ⁸⁹Sr · ¹⁵³Sm-EDTMP · ¹⁸⁶Re/¹⁸⁸Re-HEDPβ-emitter bone-pain palliationSingle-injection β-emitter therapy for pain from multifocal osteoblastic bone metastases.3 phases · 33 stepsOpen guide →
Systemic · RAI-refractory DTC
Oral multikinase inhibitor · 24 mg/dayLenvatinibOral multikinase inhibitor for radioiodine-refractory differentiated thyroid cancer (SELECT).3 phases · 17 stepsOpen guide →Oral multikinase inhibitor · 400 mg BIDSorafenibOral multikinase inhibitor for radioiodine-refractory differentiated thyroid cancer (DECISION).3 phases · 15 stepsOpen guide →Oral multikinase inhibitor · 60 mg/dayCabozantinibOral multikinase inhibitor for previously-treated radioiodine-refractory DTC (COSMIC-311).3 phases · 14 stepsOpen guide →
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