Nucpaedia
Nucpaedia
Milestones

Historical NM Gallery

The discoveries that built nuclear medicine — from radioactivity to today’s theranostics.

1896

Radioactivity discovered

Henri Becquerel observes radioactivity from uranium salts.

1934

Artificial radioactivity

Irène & Frédéric Joliot-Curie create the first artificial radionuclides.

1946

First ¹³¹I thyroid-cancer therapy

Radioiodine used to treat metastatic thyroid cancer — a founding theranostic.

1951

Rectilinear scanner

Benedict Cassen builds the first scanner to map tracer distribution.

1958

The gamma camera

Hal Anger invents the scintillation (Anger) camera — still the basis of SPECT.

1958–60

⁹⁹Mo/⁹⁹ᵐTc generator

Brookhaven develops the generator that makes ⁹⁹ᵐTc the workhorse of nuclear medicine.

1970s

SPECT

Kuhl & Edwards pioneer single-photon emission tomography.

1976

FDG synthesised

Ido, Wolf and colleagues make ¹⁸F-FDG and perform the first human studies.

1998–2001

PET/CT

Townsend & Nutt build the first PET/CT; commercial scanners arrive ~2001.

2013

²²³Ra (Xofigo)

First alpha-emitter approved (ALSYMPCA) for bone-metastatic prostate cancer.

2018

¹⁷⁷Lu-DOTATATE (Lutathera)

PRRT approved for GEP-NETs after NETTER-1.

2022

¹⁷⁷Lu-PSMA-617 (Pluvicto)

First PSMA radioligand therapy approved for mCRPC after VISION.